Video: https://www.tiktok.com/@distilledscience/video/7550438274871905567
Transcript
I just might have to try Shrooms for science. I applaud his dedication to science. He showed a study where Shrooms increased longevity. But to apply that study's effect to yourself, you need to have one particular physical trade. Let's dive in. Shrooms contain psilocybin, which gets broken down into psilocin, which is the actual psychedelic molecule. Applying a low concentration of psilocin to human cells extended their lifespan by 29%. Ten times that dose boosted it up to 57%. It lowered oxidative stress and lengthened telomeres. So next they decided to give some elderly mice an interesting time. They took 19-month-old mice, roughly the equivalent of 60 to 65 human years, and gave them psilocybin once per month for 10 months. By the 28-month-old mark, around 92 human years. Half of the control mice were dead, but 80% of the psilocybin mice were still alive. And they were showing subjective improvements in overall fur quality, including hair and reductions in white hair compared to vehicle-treated mice. So this is pretty fantastic news. If you have whiskers. And maybe those are next on the list for Immortal Unk. But what does it mean for us humans? The research said that the dose they used for the mice was based off the dose used in this human trial. I checked and it was 25 milligrams of psilocybin, which is roughly the equivalent of 2.5 grams of dried mushrooms, although those tend to vary a lot based on the specifics of the batch. But what would once per mouse month translate to with humans? There are two common ways of calculating. Based on drug metabolism speed, it will be roughly once per 8 to 14 weeks in humans. But based on relative lifespans, called Species Invariant Biological Time, it would be once every three years. Quite a difference. Unfortunately, running longevity studies on humans is really hard. But we do have some weak observational data linking psychedelic use to lowered rates of heart attacks, cancer, and depression. As well as some brain function improvement in the elderly. So I'm excited to see some better trials. I'll keep you updated.
Additional notes
References
- Psilocin/psilocybin longevity study in cells and elderly mice discussed in transcript; title/source URL/DOI/PMID not listed in workbook.
- Human psilocybin trial and observational psychedelic-health data mentioned in transcript; direct source details not listed in workbook.