Transcript
Coffee Science Time. Your genes could completely flip how coffee impacts your blood pressure. Last video we talked about an enzyme called CYP 182, which impacts how your body breaks down chemicals, toxins, and caffeine. Its function is influenced by a particular genetic snip that makes you either a fast, medium, or slow caffeine metabolizer. You may know who you are. How many cups have you had this morning? None. Plus? Five. Last video we saw how it can make coffee either help or hurt athletic performance. Now let's see a new study, where researchers looked at over 500 men and women over the course of eight years. They all started with moderately high blood pressure, but 323 developed hypertension that required treatment. But here's where it gets interesting. For those who drank 4 plus cups of coffee per day, the medium and slow metabolizers were three times as likely to develop hypertension. Whereas for the past metabolizers, the more coffee they drank, the less likely they were to develop it. Almost 1 third as likely for 4 plus cups per day. The study was 72% men, but the exact same results were seen with the women. But if you are slow metabolizer, not all is lost. Another study duplicated these results. But they also discovered that for slow metabolizers, Exercise eliminated the negative effects of caffeine on blood pressure. So get moving.
Additional notes
Is caffeine bad for you? As with most cases in non-sensationalized-science, It all depends on the “you,” both in terms of genetics and behavior. The gene to look up: RS762551 Last video we talked about an enzyme called CYP1A2 which helps our body break down many chemicals, toxins, AAND caffeine. It’s function is influenced by a particular genetic SNP that makes some people fast, medium, or slow metabolizers. (You may know who you are) (I’m a fast metabolizer) Last time we saw how it can make coffee help or hurt athletic performance. Now let’s see a new study, where researchers looked at 553 men and women with moderately high blood pressure over 8 years, during which time 323 developed hypertension that required treatment (high blood pressure). For those who drank 4+ cups of coffee per day, the medium and slow metabolizers were 3 times as likely to develop hypertension, whereas for the fast metabolizers, the more coffee they drank, the LESS likely they were to develop it! Almost 1/3 as likely for 4+ cups per day. This study was 72% men, but the exact same results were seen in the women. But if you’re a slow metabolizer, not all is lost: another study duplicated this one’s results, BUT they also discovered that for slow metabolizers, exercise eliminated the negative effects of caffeine on blood pressure. Study Links Coffee+BP1: DOI: 10.1097/HJH.0b013e32832ba850 Coffee+BP+Exercise: DOI:10.1016/j.vph.2018.03.002 Caffeine + Exercise: DOI: 10.1249/MSS.0000000000001596 #science #coffee #learnontiktok #edutok #tiktoklearningcampaign
References
- Coffee+BP1. DOI: 10.1097/HJH.0b013e32832ba850. Source: https://doi.org/10.1097/HJH.0b013e32832ba850
- Coffee+BP+Exercise. DOI: 10.1016/j.vph.2018.03.002. Source: https://doi.org/10.1016/j.vph.2018.03.002
- Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes. DOI: 10.1249/MSS.0000000000001596. Source: https://doi.org/10.1249/MSS.0000000000001596