The Truth About O-Zempic and Bone Health

Video: https://www.tiktok.com/@distilledscience/video/7467366872795581726

Transcript

Does O-Zempic make her body eat its own bones? Can you reverse it? What the science? Avery's story went viral last week. She took O-Zempic without a doctor's oversight, and now she has osteoporosis. Which is not a deadly bone-thening disease, which implies something ongoing, but it is the state of having low bone density. Avery, I'm sorry, it's not your fault. The real problem here is predatory clinics pushing miracle weight loss drugs without proper physician oversight. I have osteopenia, which is low bone density. So this hits home. And if you're on O-Zempic or just worried about your bone health, this video is for you. L.P1 receptor agonist. Let's call it a glupa. It mimics a natural compound called GLP1, gloop, that our bodies produce after eating. It delays stomach emptying, boosts insulin production, and overall makes you want to eat less. And unlike natural gloop, OZempic sticks around all week rather than levels going down after eating, hence the weight loss. But as for bone, I've seen people cite this meta-analysis of seven studies where the abstract says, glupas did not affect bone mineral density or bone formation markers. But if you look deeper, you'd see that in six out of the seven studies, they all used an older glupa. The seventh did show some bone density loss, and that was the only one that used semaglutide, aka ozempic. It also showed an increase in bone resorption markers, meaning that the body was reabsorbing some of its own bone. Why? In bone science, there's a rule called Wolf's Law. Bones adapt to stress, its presence or absence. Sorry, stressing about your bones doesn't count, but lose some weight and your bones might weaken because they're no longer under pressure. A 10% weight loss often comes with a one to two to two, bone density loss, which is a lot. And the difference between the new glupas and the old glupas is that the new ones are much better at causing weight loss. In that seventh study, they lost an average of 15 pounds. But you can use this knowledge to change for the better. 1. Lift heavy weights, 70 to 90% of your 1 rep max. Compound lifts like squats that load the skeleton are ideal. 2. Get it off calcium, magnesium, vitamins D3 and K2. Diet is best, then come supplements. I'll do another video about those soon. 3. Try wearing a weighted vest. It tricks your body into thinking that it's heavier, continuously loading the skeleton and boosting bone density. It's best to start light and work your way up in weight and time worn. And you can add jumping exercises for maximum impact. And if someone looks at you funny, you can just tell them that you're doing it because glupa's made you fear the wolf. They won't think you're crazy at all. For science.

Additional notes

If you’re on Ozempic or worried about bone health, talk to your doctor—and share this with someone who needs toI see it. Let’s spread science, not fear. 🦴✨ 🗒️ Note 1: bone resorption is a totally normal process. Ideally, we have a nice balance between bone resorption and formation. In postmenopausal women, as estrogen levels drop, this balance often shifts more towards the resorption–which is what most osteoporosis drugs try to target. 🗒️ Note 2: a large percentage of bone density is determined solely by genetics. I have over a dozen genetic variants that I KNOW are associated with poor bone health. I bet that Avery has similar, which likely lead to her having low bone density even before the Ozempic, and it was then just exacerbated somewhat by taking it. Most people never even get a bone density scan when they’re young, unless they have an abnormal number of bone breaks or fractures (like me :/ ) ⚠️ This video was a small snapshot from a larger article I’m working on about All Things Bone Density. If you want to make sure not to miss it, it will be going out with my newsletter soon! 📚References DOI: 10.1002/dmrr.3843 DOI: 10.1093/jn/136.6.1453 DOI: 10.1016/j.eclinm.2024.102624 PMID: 35208548 DOI: 10.1093/gerona/55.9.M489 #science #bonedensity #stem #edutok

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